Abstract
Epidermal cell ‘dyskeratosis’ that appeared after ultraviolet (UV) irradiation of mouse skin was found to be most marked during a time when kinetic studies showed there was complete suppression of epidermal cell proliferative activity. Sheet preparations of epidermis showed that ‘dyskeratosis’ affected basal cells in both the central and peripheral zones of individual epidermal proliferative units, and caused a marked reduction in the number of cells in this epithelial layer. Electron microscopy of the degenerate epidermal cells showed that they were keratinocytes that had undergone morphologically typical apoptosis, an ultrastructurally distinctive form of individual cell death characterized by both nuclear and cytoplasmic condensation and fragmentation. Most of these cell fragments were engulfed and degraded by adjacent surviving keratinocytes, but some were phagocytosed by Langerhans cells. It is suggested that apoptosis following UV irradiation occurs in cells that are unable to repair the genetic damage that is inflicted by this form of injury. Death occurring during mitosis, or as a result of accelerated differentiation, does not appear to be involved.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
