Abstract
背景与目的CT引导下穿刺活检（computed tomography-guided needle biopsy, CTNB）是诊断肺癌最常用的一种方法，具有诊断准确性高及并发症少的特点。现有的研究表明CTNB可引起肿瘤的针道转移，然而极少有研究关注CTNB对远处转移和远期生存的影响。本研究旨在探讨术前的CTNB对Ⅰ期-Ⅱ期非小细胞肺癌（non-small cell lung cancer, NSCLC）远处转移和生存的影响。方法研究对象为1, 234例Ⅰ期-Ⅱ期NSCLC术后患者，其中113例术前行CTNB，1, 121例术前未经任何活检。应用倾向性评分匹配方法平衡两组间的临床特征，经配对后纳入后续统计检验共226例。并进一步应用Cox回归分析法和Kaplan-Meier分析法进行生存分析。结果在Ⅰ期-Ⅱ期NSCLC患者中，术前的CTNB组无远处转移时间（distant metastasis free survival, DMFS）显著短于无活检组（P=0.032），而两组间总生存无统计学差异（P=0.086）。结论CT引导下穿刺肺活检可能促进早期肺癌的远处转移，但不影响总生存。
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