Abstract
Eleven different compounds representing various classes of buffering agents were studied with respect to their effect on the dissolution of aspirin from tablet formulations. In general, carbon dioxide-producing buffering agents (sodium bicarbonate, magnesium carbonate, and calcium carbonate) gave more rapid dissolution than the readily water-soluble buffering agents (sodium ascorbate and sodium citrate), and both of the preceding classes of buffering agents gave much faster dissolution than water-insoluble buffering agents such as magnesium and aluminum compounds.
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