Abstract
IntroductionCryptococcus neoformans is an encapsulated yeast that causes serious infections in immunocompromised populations. The majority of cases occur in HIV-infected individuals. Disseminated disease is uncommon, and very rarely includes peritonitis.Case presentationWe report a case of a 41-year-old, HIV-negative, Caucasian man with alcoholic liver cirrhosis who presented with fever and seizure. Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia was diagnosed, and despite adequate treatment the patient developed multi-system organ failure and eventually expired.ConclusionDisseminated cryptococcosis, particularly with peritonitis, is an uncommon manifestation of Cryptococcus neoformans infection. Liver cirrhosis serves as a risk factor for disseminated disease in HIV-negative patients. A high clinical suspicion and early initiation of therapy is needed to recognize and treat patients effectively.
Highlights
Cryptococcus neoformans is an encapsulated yeast that causes serious infections in immunocompromised populations
Liver cirrhosis serves as a risk factor for disseminated disease in HIV-negative patients
We present a case of disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia occurring in a HIV-negative patient with alcoholic liver cirrhosis
Summary
Disseminated cryptococcosis, with peritonitis, is an uncommon manifestation of C. neoformans infection. Liver cirrhosis serves as a risk factor for disseminated disease in HIV-negative patients and is associated with a grave prognosis. A high clinical suspicion and early initiation of therapy is needed to recognize and treat patients effectively. The patient expired and despite multiple attempts to contact the family, the of kin was not available. The patient case is presented anonymously, and there is no reason to think that the patient or their family would object to publication
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