Disparities in HPV vaccination in young vs. older Hispanic adults and genital HPV prevalence (378)

Abstract

<b>Objectives:</b> To compare the human papillomavirus (HPV) vaccination rates in young versus older women and correlate with genital HPV infection rates in the United States. <b>Methods:</b> HPV vaccination rates for teenage girls (13-17 years) were evaluated using the Centers for Disease Control and Prevention's TeenVax dataset between 2008 and 2018. HPV vaccinations rates on women (18-49 years) were obtained from the Behavioral Risk Factor Assessment Monitoring System from 2008 to 2016. Trends were described using average annual percent change (AAPC). Data on HPV infection were obtained on women (20-59 years) from the National Health and Nutrition Examination Survey from 2011 to 2016. HPV infection was detected through vaginal swab samples and analyzed using the Roche Linear Array HPV Genotyping Test. <b>Results:</b> Between 2008 and 2016, HPV vaccination increased annually from 3.0% to 15.1% at an increase of 23.4% per year (p<0.001). The vaccination rates for the 13-17 years versus 18-24 and 25-29, 30-34, 35-39, 40-44, 45-49 were 57.4%, 44.1%, 33.2%, 14.56%, 5.96%, 3.98%, and 2.65%, respectively. In 2018, HPV teenage vaccination rates were 61.7%, 60.6%, 57.7%, 54.2% in Hispanic, Black, Asian, and White, respectively. Between 2011 and 2016, 46.0% of other Hispanic and 35.2% of Mexican American tested positive for any genital HPV compared to 32.0% of White women (p<0.0001). On multivariate analysis, we found that other Hispanic race (OR: 1.88, p<0.0001), income below the poverty line (OR: 1.38, p=0.0072), low income (OR: 1.34, p=0.03), divorced/separated (OR: 1.67, p=0.004) and more than four lifetime sexual partners (OR: 2.69, p<0.0001) were predictors of HPV infection. <b>Conclusions:</b> Overall, HPV vaccination rates increased in both teenage and adult women. However, we found that Hispanics had higher vaccination rates as teens compared to adults.