Abstract

SINCE 1942, when the last review of this subject appeared in the Journal, 1 there have been many important advances in the understanding of the biochemistry and physiology of the thyroid gland. In addition, a new group of substances that are goitrogenic and at the same time markedly depress thyroid function have been extensively investigated. Radio-iodine, which has been widely used in the investigation of thyroid physiology and iodine metabolism, has reached the stage of clinical usefulness in the treatment of toxic goiter. The value of blood iodine studies continues to be demonstrated, with chief emphasis on the protein-bound iodine of . . .

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