Abstract
The μ-opioid receptor subtypes involved in the discriminative stimulus properties of morphine were investigated in rats that had been trained to discriminate between 3.0 mg/kg morphine and saline. The discriminative stimulus properties of morphine were significantly attenuated by β-funaltrexamine (an irreversible μ-opioid receptor antagonist: 10 and 20 mg/kg) and naloxonazine (an irreversible μ 1-opioid receptor antagonist: 20 mg/kg). These results suggest that the discriminative stimulus properties of morphine may be mediated by μ 1-opioid receptors.
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