Abstract
A total of 205 pyramidal tract neurons recorded extracellularly from normal and epileptic cortex were studied with respect to spontaneous and evoked activity. Clear differences could be ascertained between cells injured in normal cortex and cells injured in epileptic cortex. In epileptic cortex it was common for injury-induced repetitive firing to closely mimic burst firing which was believed to represent spontaneous epileptic activity. Distinctions between normal and epileptic cortex could be determined by two criteria: (i) stability of cell firing patterns over time under constant behavioral conditions, and (ii) stability of cell firing patterns as a function of microelectrode manipulation. It appears relevant that cells recorded from gliotic cortex appear more mechanosensitive than those recorded from normal cortex or penicillin epileptic cortex. This implication is discussed as a potential contributing factor in chronic experimental epileptic foci.
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