Abstract
The infiltration of leukocytes is a specific, rather than a random, event, and regulated by the production of chemoattractants that specifically attract a certain type of leukocytes. By early 1980s, chemoattractants, now referred as “classical chemoattractants,” including the bacterial peptide N-formyl-methionyl-leucyl-phenylalanine (FMLF), the C5a fragment of serum complement and the lipid mediator leukotriene B4 (LTB4), had been identified. However, FMLF and C5a lacked cell specificity and attracted both neutrophils and monocytes. LTB4 exhibited both chemotactic and chemokinetic activities for phagocytes. There were several reports suggesting the existence of other cytokine-like chemoattractants. Lymphocyte-derived chemotactic factor (LDCF) was detected in the culture supernatant of mitogen-activated peripheral blood mononuclear cells (PBMC) (1). A neutrophil chemoattractant was also present in the culture supernatant of activated monocytes or macrophages (2). However, these cytokine-like chemoattractants were not purified or cloned.
Highlights
The infiltration of leukocytes is a specific, rather than a random, event, and regulated by the production of chemoattractants that attract a certain type of leukocytes
These findings suggested that cytokine-like chemoattractants produced by activated mononuclear leukocytes reported earlier could be attributed to interleukin 1 (IL-1) and/or TNF
Since we were very intrigued to learn that the cytokine IL-1 was chemotactic for neutrophils and monocytes, we decided to examine the chemotactic activity of IL-1 in more detail
Summary
The infiltration of leukocytes is a specific, rather than a random, event, and regulated by the production of chemoattractants that attract a certain type of leukocytes. Lymphocyte-derived chemotactic factor (LDCF) was detected in the culture supernatant of mitogen-activated peripheral blood mononuclear cells (PBMC) [1]. A neutrophil chemoattractant was present in the culture supernatant of activated monocytes or macrophages [2].
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