Abstract
The behavior of magnesium octa[(4'-benzo-15-crown-5)oxy]phthalocyaninate (Mgcr8Pc) in aqueous micellar solutions of alkyltriphenylphosphonium bromides (CnTPPBs), where n = 8, 12, 14, and 16, has been studied by means of electronic absorption spectroscopy and measurements of fluorescence photophysical characteristics. Intense bands of absorption (λmax = 683 nm) and fluorescence (λmax = 694 nm) of Mgcr8Pc in CnTPPB micellar solutions are characterized by monoexponential decay of intensity (lifetime of 5.98–6.29 ns) and indicate that magnesium phthalocyaninate has the monomeric form. The disaggregation of Mgcr8Pc in the presence of CnTPPBs provides an opportunity to use aqueous micellar solutions containing this metallophthalocyane in photodynamic therapy, because it is the monomeric form of Mgcr8Pc that generates singlet oxygen molecules, which kill tumor cells.
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