Abstract
3-(Fluoroalkyl)pyrazoles 3 have been synthesized in excellent yields by reaction of various fluoroalkyl aldehydes with NH2NH2·HOAc under mild conditions. It appears that the reaction involves the formation of a hydrazone intermediate, followed by elimination of hydrogen halide and intramolecular nucleophilic addition. A practical one-pot synthesis of 3-(fluoroalky1)pyrazoles from polyfluoroalkyl iodides 1 has also been developed.
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Schedule a callMore From: Journal of the Chemical Society, Perkin Transactions 1
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