Abstract
Methods that allow the production of patterned surfaces at the nanometer scale are powerful tools for studying fundamental aspects of cell adhesion at the level of single protein/ receptor molecules, [1] tissue engineering, [2] and cellular biosensing. [3] Furthermore, patterning of biomolecules is also a challenging issue for the implementation of a new generation of miniaturized biochips requiring smaller reagent quantities with lower detection limits. Nanopatterned surfaces have already demonstrated the potential to fulfill these requirements, and recent results have indicated that a strong increase in the detection sensitivity of immunosensors was obtained when antibodies were immobilized on nanostructured surfaces. [4]
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