Abstract
Diagnostic lung imaging is often associated with high radiation dose and lacks sensitivity, especially for diagnosing early stages of structural lung diseases. Therefore, diagnostic imaging methods are required which provide sound diagnosis of lung diseases with a high sensitivity as well as low patient dose. In small animal experiments, the sensitivity of grating-based X-ray dark-field imaging to structural changes in the lung tissue was demonstrated. The energy-dependence of the X-ray dark-field signal of lung tissue is a function of its microstructure and not yet known. Furthermore, conventional X-ray dark-field imaging is not capable of differentiating different types of pathological changes, such as fibrosis and emphysema. Here we demonstrate the potential diagnostic power of grating-based X-ray dark-field in combination with spectral imaging in human chest radiography for the direct differentiation of lung diseases. We investigated the energy-dependent linear diffusion coefficient of simulated lung tissue with different diseases in wave-propagation simulations and validated the results with analytical calculations. Additionally, we modeled spectral X-ray dark-field chest radiography scans to exploit these differences in energy-dependency. The results demonstrate the potential to directly differentiate structural changes in the human lung. Consequently, grating-based spectral X-ray dark-field imaging potentially contributes to the differential diagnosis of structural lung diseases at a clinically relevant dose level.
Highlights
IntroductionS TRUCTURAL lung diseases change the microstructure of the human lung parenchyma and increase the risk of
Examples of the lung parenchyma phantoms based on Voronoi grids for fibrosis, healthy lung tissue and emphysema are depicted in Fig. 3 (a)
We found that an increase in mean wall thickness (MWT) is related to an increase in energy-dependency b and a decrease in mean chord length (MCL) is related to an increase in signal strength
Summary
S TRUCTURAL lung diseases change the microstructure of the human lung parenchyma and increase the risk of. Herzen are with the Chair of Biomedical Physics, Department of Physics, Munich School of BioEngineering, Technical University of Munich, 85748 Garching, Germany
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