Abstract
AbstractA direct catalytic asymmetric Mannich‐type reaction of benzyl isocyanide using a CuI catalyst and N‐(diphenylthiophosphinoyl)imines was developed. The simultaneous activation strategy by soft–soft interaction was the key to promote the reaction using a weakly acidic pronucleophile, benzyl isocyanide. The spontaneous cyclization of the Mannich adduct afforded the corresponding enantioenriched imidazolines, which could be precursors for a variety of 1,2‐diarylethylenediamines.
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