Abstract
Anxiety sensitivity and distress tolerance are both hypothesized risk factors for generalized anxiety disorder (GAD) and major depressive disorder (MDD). However, it is unclear whether these factors synergistically influence GAD and MDD and related symptoms. Using latent variable methods, direct and interactive relations between anxiety sensitivity and distress tolerance with worry and depressive symptoms and with GAD and MDD diagnoses were examined in 347 outpatients. Interactive effects of anxiety sensitivity and distress tolerance were found for worry and GAD/MDD. The interactions generally suggested that anxiety sensitivity confers a greater risk for worry and GAD/MDD at higher levels of distress tolerance, and that distress tolerance confers a greater risk for worry and GAD/MDD at lower levels of anxiety sensitivity. Given the interactive effects of anxiety sensitivity and distress tolerance for GAD/MDD, interventions targeting both risk factors may prove more efficacious than targeting each individually.
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