Abstract
A growing body of evidence suggests that tricyclic antidepressant agents (TCAs) interact with GTP binding proteins (G proteins). We have investigated if TCAs directly alter the function of the purified G o protein which is specifically expressed in neuronal tissue. Several TCAs markedly enhanced the GTPase activity of G o protein in a pertussis toxin-susceptible manner, whereas MAO-inhibitor and anxiolytic agent did not. This enhancing effect of TCAs on G o function may be due to an increase in the GDP-GTP exchange reaction occurring on G o. Thus, it is very likely that TCAs can modify various signal transduction by directly interacting with G proteins in brain cells.
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