Abstract
From the reaction of tert-butyl lithium or n-butyl lithium with N-methylpyrrole ( 1a), furan ( 1b) or 2-bromo-thiophen ( 1c), 2- N-methylpyrrolyl lithium ( 2a), 2-furyl lithium ( 2b) or 2-thiophenyl lithium ( 2c), respectively, was obtained. When reacted with 6-(2- N-methylpyrrolyl) fulvene ( 3a), 6-(2-furyl) fulvene ( 3b) or 6-(2-thiophenyl) fulvene ( 3c), the corresponding lithiated intermediates were formed ( 4a– c). Titanocenes ( 5a– c) were obtained through transmetallation with titanium tetrachloride. When these titanocenes were tested against pig kidney epithelial (LLC-PK) cells, inhibitory concentrations (IC 50) of 32 μM, 140 μM, and 240 μM, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, compared to their ansa-analogues.
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