Abstract
Diffusion ordered 2D NMR (DOSY) has been used to characterize large unilamellar phospholipid (LUV) vesicles. Entrapped sucrose served as an NMR active label for the vesicles and permitted diffusion coefficients to be measured for vesicle preparations with average diameters ranging from 30 to 100 nm and total lipid concentrations ranging from 1 to 30 mM. Distributions of diffusion coefficients were obtained by analysis with the program CONTIN. Average diameters and distributions of diameters were been obtained from the vesicle diffusion coefficients after appropriate corrections by means of the Stokes-Einstein equation. Electron microscopy and dynamic light scattering measurements were also performed on the LUV's, and the results were found to be consistent with those obtained with DOSY
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