Abstract
Objective: To explore the relation between diffusion-weighted and susceptibility weighted imaging (DWI-SWI) mismatch and collateral circulation or prognosis in patients with occluded M1 segments of middle cerebral artery (MCA).Methods: We enrolled 59 patients with MCA M1-segment occlusion for a retrospective review of baseline clinical and imaging data. As markers of circulatory collaterals, prominent laterality of posterior (PLPCA) and anterior (PLACA) cerebral arteries on magnetic resonance angiography (MRA) studies and a hyperintense vessel sign (HVS) on T2 fluid-attenuated inversion recovery (FLAIR) images were collectively scored. The extent of acute cerebral infarction was then quantified on DWI, using the Alberta Stroke Program Early CT Score (DWI-ASPECTS). Hypointensity vessel sign prominence (PVS) was also evaluated by SWI and similarly scored (SWI-ASPECT) to calculate DWI-SWI mismatch [(DWI-ASPECTS) – (SWI-ASPECTS)], ranging from −10 to 10 points.Results: DWI-SWI mismatch showed significant associations with PLPCA, PLACA, HVS prominence, and collective collateral scores (all, p < 0.05). National Institutes of Health Stroke Scale (NIHSS), DWI-SWI mismatch, and DWI-ASPECTS also differed significantly according to patient prognosis (good vs. poor) after MCA M1-segment occlusion (p < 0.05). In binary logistic regression analyses, NIHSS and DWI-SWI mismatch emerged as independent prognostic factors (p < 0.05).Conclusions: Collateral circulation may be an important aspect of DWI-SWI mismatch, which in this study correlated with prognostic outcomes of MCA M1-segment occlusion.
Highlights
Occlusion of the middle cerebral artery (MCA) is a major cause of anterior circulation strokes, clinical outcomes may vary as a function of collateral circulation
National Institutes of Health Stroke Scale (NIHSS), diffusion-weighted imaging (DWI)-Susceptibility weighted imaging (SWI) mismatch, and DWI-ASPECTS differed significantly according to patient prognosis after MCA M1-segment occlusion (p < 0.05)
In binary logistic regression analyses, NIHSS and diffusion-weighted and susceptibility weighted imaging (DWI-SWI) mismatch emerged as independent prognostic factors (p < 0.05)
Summary
Occlusion of the middle cerebral artery (MCA) is a major cause of anterior circulation strokes, clinical outcomes may vary as a function of collateral circulation. Prominent laterality of posterior (PLPCA) and anterior (PLACA) cerebral arteries observed by magnetic resonance angiography (MRA) and a hyperintense vessel sign (HVS) on T2 fluid-attenuated inversion recovery (FLAIR) images have shown clear associations with both collateral vessels and patient prognosis [1, 2]. Some studies have linked diffusion- and susceptibility weighted imaging (DWI-SWI) mismatch to the penumbra after MCA occlusion [6, 7]. The present investigation was undertaken to examine the relation between DWI-SWI mismatch and collateral circulation or prognosis in patients with occluded M1 segments of MCA
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