Abstract
The distal rectosigmoid of the developing embryonic rat was studied on each gestational day from 12 to 21. Circular muscle was first recognized on day 16 and ganglion cells on day 17. When in vitro dissociated colon from as early as the day 12 embryo reached a maturational age of 17 days (embryonic age plus days in culture), circular muscle, ganglia, and peristalsis could be detected. This indicates that neuroblasts must have migrated to the indifferent mesenchyme before day 12 of gestation. Anti-nerve growth factor immunoglobulin-G (IgG) did not inhibit differentiation of ganglia in vitro. As a result of this study we designed an in vitro assay that can serve as a useful means to study isolated ganglion cell development.
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