Abstract
J.R. BOISSIER, J.F. GIUDICELLI, S. LARNO and C. ADVENIER, Differential inotropic-chronotropic action of thyronamine, European J. Pharmacol. 22 (1973) 141–149. The cardiovascular and hemodynamic effects of thyronamine have been investigated in anesthetized dogs. Thyronamme produced dose-related increases in myocardial contractile force, cardiac output and left ventricular work but did not affect heart rate. These actions were not affected by atropinization or by bilateral vagotomy. However, the positive inotropic effects of thyronamine were completely abolished in dogs and almost completely abolished in isolated guinea-pig atria by prior administration of reserpine or by β-adrenergic blockade. These results suggest that thyronamine acts mainly by releasing endogenous catecholamines acting on β-adrenergic inotropic receptors. The differential inotropic-chronotropic effects of thyronamine, which resemble those of dopamine, suggest that the β 1-type adrenoceptors are not homogeneous and that inotropic and chronotropic receptors may differ from each other.
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