Abstract
BackgroundTo determine the levels of connective tissue growth factor (CTGF) and hepatocyte growth factor (HGF) in the vitreous of patients with high myopia, in comparison with those with a vitreomacular interface disease (VMID).MethodsPatients with either high myopia (high myopia group) or a VMID (VMID group) were included in this study. Each of the two groups were further subdivided into two subgroups: group A (high myopia with macular hole), group B (high myopia with macular retinoschisis), group C (idiopathic macular hole), and group D (idiopathic epiretinal membrane). Vitreal specimens were collected during vitrectomy, and enzyme-linked immunosorbent assay was used to quantitatively measure the CTGF and HGF levels in the vitreous.ResultsThe average axial length was markedly longer in the high myopia group than in the VMID group. The vitreal CTGF level was significantly higher in the high myopia group than in the VMID group. Subgroup analysis revealed significantly higher vitreal CTGF in group A than in the other three subgroups. The vitreal HGF level was not significantly different between the high myopia and VMID groups, but was significantly higher in group D than in group C in the subgroup analysis. Correlation analysis showed that the vitreal CTGF level was positively correlated with the axial length.ConclusionsThe vitreal CTGF level is elevated in highly myopic eyes and may be related to the pathogenesis of high myopia, whereas increased expression of HGF may be involved in the development of idiopathic epiretinal membrane.
Highlights
To determine the levels of connective tissue growth factor (CTGF) and hepatocyte growth factor (HGF) in the vitreous of patients with high myopia, in comparison with those with a vitreomacular interface disease (VMID)
We investigated the changes in CTGF and HGF levels in the vitreous of patients with high myopia. We evaluated these vitreal cytokines in patients with the vitreomacular interface diseases (VMIDs) of idiopathic macular hole and idiopathic epiretinal membrane
Subjects We performed an observational study of patients with either high myopia or a VMID (VMID group) who underwent vitrectomy surgery at the Eye and ENT Hospital of Fudan University, China
Summary
To determine the levels of connective tissue growth factor (CTGF) and hepatocyte growth factor (HGF) in the vitreous of patients with high myopia, in comparison with those with a vitreomacular interface disease (VMID). According to an epidemiological study, the incidence of high myopia is increasing.. High myopia is characterized by progressive elongation of the eyeball, scleral thinning, and formation of posterior. Myopia is caused by remodeling of the scleral extracellular matrix. Animal studies indicate that cytokines and proteinases are involved in the scleral remodeling processes during the development of myopia. Previous studies have focused mainly on transforming growth factor (TGF)-β and matrix metalloproteinases (MMPs) [6,7,8]. We previously measured TGF-β2 and MMP-2 levels in the vitreous of patients with high myopia and
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
