Differential efficacy of human mesenchymal stem cells on disease in murine lupus based on source of origin.

Abstract

Event Abstract Back to Event Differential efficacy of human mesenchymal stem cells on disease in murine lupus based on source of origin. Erin L. Collins1*, Fei Gu2, Osama Naga1 and Gary Gilkeson1 1 Medical University of South Carolina, Department of Medicine, United States 2 The Affiliated Drum Tower Hospital of Nanjing University Medical School, Department of Rheumatology, China Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that targets multiple organ systems. A population of non-hematopoetic stem cells, mesenchymal stem cells (MSC), are of increasing interest as a therapeutic option for autoimmune diseases such as SLE. MSCs can be derived from various sources such as bone marrow or umbilical cords. In this study we examine the efficacy of human MSCs with varying origin on disease in murine based lupus. Human MSCs were harvested from umbilical cords, healthy donor bone marrow, and lupus patient bone marrow. We showed that in MRL/lpr mice, MSCs from all sources improved survival, increased body weight, and decreased proteinuria. Glomerular IgG, but not C3, deposition is significantly decreased in mice receiving umbilical cord and healthy donor MSCs. However, MSC from lupus patients caused a significant increase in glomerular C3 and IgG. Although no differences were seen in the percentage of CD4+ or CD8+ T, mice receiving lupus MSCs experienced a 2-fold increase in the percentage of Foxp3+ cells in the spleen. These mice also experienced this percentage increase in TCRβ+, B220+, and CD138+ cells in the bone marrow. Human MSC from various origins all made an impact on the disease severity of lupus prone mice. However, these results suggest that MSCs from healthy donors or umbilical cords appear to me more effective in murine lupus than the MSCs derived from lupus patients. Keywords: Mesenchymal stem cells (MSC), Autoimmunity, systemic lupus erythematosus (SLE), Nephritis, cell therapy Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: Collins EL, Gu F, Naga O and Gilkeson G (2013). Differential efficacy of human mesenchymal stem cells on disease in murine lupus based on source of origin.. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00580 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Erin L Collins, Medical University of South Carolina, Department of Medicine, Charleston, South Carolina, 29404, United States, collinel@musc.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Erin L Collins Fei Gu Osama Naga Gary Gilkeson Google Erin L Collins Fei Gu Osama Naga Gary Gilkeson Google Scholar Erin L Collins Fei Gu Osama Naga Gary Gilkeson PubMed Erin L Collins Fei Gu Osama Naga Gary Gilkeson Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.