Abstract
Potentially favorable effects of wine consumption on colorectal cancer (CRC) incidence have been reported, but effects on clinical outcomes are unknown. This case-only analysis was designed to investigate outcomes among familial (n = 141) and sporadic (n = 358) CRC patients enrolled in the University of California Irvine CRC gene-environment study during 1994–1996 based on their reported frequency of wine consumption in the year prior to diagnosis. Cases were categorized as either regular or infrequent wine consumers. Univariate survival rate analyses were estimated using the Kaplan and Meier method and log-rank test. Multivariate survival analyses were performed using Cox proportionalhazards ratios (HRs). Earlier stage at presentation (P = 0.034) was noted for familial (but not sporadic) CRC cases reporting regular wine consumption. An overall survival (OS) benefit was observed for familial (but not sporadic) CRC cases that were regular (10-yr OS = 75%) versus infrequent wine consumers (10-yr OS = 47%; P = 0.002). This survival improvement for familial CRC cases remained after adjustment for age, stage, treatment, and other clinically relevant factors (HR = 0.50, 95% confidence interval = 0.25–0.99). Our findings implicate favorable effects of wine consumption on stage at presentation and survival in CRC, selectively among familial CRC cases. * Dr. Anton-Culver and Dr. Holcombe contributed equally as co-senior investigators for this research.
Highlights
Alcohol consumption has been associated with an increased risk of developing colorectal cancer (CRC)
In a large population-based cohort study analyzing 28,000 individuals, alcohol intake was associated with an increased risk of rectal cancer; this risk was diminished in alcohol drinkers who consumed at least some wine versus those who did not drink any wine at all [10]
A greater proportion of cases with local stage at presentation was noted for familial CRC cases compared to sporadic CRC cases
Summary
Alcohol consumption has been associated with an increased risk of developing colorectal cancer (CRC). One large meta-analysis reported an increased relative risk of 1.1 for developing CRC when consuming more than 2 alcoholic beverages per day [1]. Total alcohol consumption has been shown to increase the risk of developing CRC in familial cases through an interaction with family history by several investigators, but the effects of wine have not been assessed [4,5,6]. Controversy over this issue remains, as it has been reported that the risk of developing CRC may depend on the type of alcoholic beverage consumed.
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