Abstract
Imipramine-induced enhancement of the inhibitory action of 5-HT lA receptor activation in hippocampal pyramidal neurons has been attributed to alterations in the transduction mechanism that involves G protein-dependent opening of K + channels. Postsynaptic 5-HT lA and adenosine Al receptors may share that transduction pathway. We investigated the influence of repeated imipramine administration on 5-HT lA and adenosine A1 receptor-mediated effects in rat hippocampal slices. Repeated imipramine selectively enhanced the postsynaptic effects of 5-HT 1A receptor activation, including hyperpolarization and reduction of input resistance of neurons and reduction of the population spike amplitude. In contrast, after imipramine treatment only the presynaptic effect of adenosine receptor agonists, a decrease of the field excitatory postsynaptic potential, was enhanced. The data demonstrate that alterations in the presumed common transduction mechanism that was postulated for the 5-HT lA and adenosine A1 receptor-mediated activation of K + channels are not involved in the effect of repeated imipramine administration.
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