Differential effect of stress on neurogenesis in rat adult central nervous system

Abstract

Event Abstract Back to Event Differential effect of stress on neurogenesis in rat adult central nervous system Mohamed Najimi1*, Fatiha Chigr1, Fatima Rachidi1, Stéphanie Ségura2, Jérôme Trouslard2 and Emmanuel Moyse2 1 Université Sultan Moulay Slimane, Laboratoire “Génie Biologique”, Morocco 2 Université Aix Marseille 3, CRN2M, Labo PNV, France The production of new neurons has until recently been considered to occur only during the embryonic and early postnatal periods with no significant role in the adult brain. It is now well accepted that neurogenesis occurs in several parts of the adult brain of mammals. Two regions have been defined as neurogenic niches, namely, the olfactory bulb and hippocampus. Recently, we have shown that also the dorsal vagal complex (DVC) in the rat brainstem displays adult neurogenesis. The new born neurons arise from neural progenitor cells located within the DVC itself. The DVC is considered as one of the key centres involved in food intake regulation. This function is highly sensitive to environmental influences like stressful conditions. Interestingly, stress affects negatively neurogenesis, notably in the hippocampus. However, how stress affects neurogenesis in DVC in relation to food intake regulation remains an unaddressed question. This represents the main goal of the present investigations. Using a homotypic and unpredictable stress paradigm (immobilization used repetitively during 3 weeks), we noticed that stress reduces significantly the rates of cell proliferation and differentiation in the DVC. The most dramatic influence of stress occurred in the area postrema, where the decrease reached about 50%, when compared to a 25-30% decrease in the nucleus tractus solitarius (NTS) and dorsal motor nucleus of the vagus (DMNV). Chronic immobilization stress induced a significant decrease of the total neurosphere number per rat DVC in both primary and secondary cultures, indicating that intrinsic neural stem cell frequency was decreased by chronic stress in DVC tissue. This stress paradigm elicits also a significant reduction of neurogenesis in the hippocampus (28%) whereas olfactory bulb seems to display an opposite response. Acknowledgment: GDRI Neuro (CNRS-CNRST, France – Maroc), PICS CNRS-CNRST (France Maroc), Université Aix Marseille 3 Conference: 2nd NEUROMED Workshop, Fez, Morocco, 10 Jun - 12 Jun, 2010. Presentation Type: Oral Presentation Topic: Oral Session 2: Adaptation to environmental stress Citation: Najimi M, Chigr F, Rachidi F, Ségura S, Trouslard J and Moyse E (2010). Differential effect of stress on neurogenesis in rat adult central nervous system. Front. Neurosci. Conference Abstract: 2nd NEUROMED Workshop. doi: 10.3389/conf.fnins.2010.12.00030 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Jun 2010; Published Online: 04 Jun 2010. * Correspondence: Mohamed Najimi, Université Sultan Moulay Slimane, Laboratoire “Génie Biologique”, Béni-Mellal, Morocco, mnajimi1@fstbm.ac.ma Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mohamed Najimi Fatiha Chigr Fatima Rachidi Stéphanie Ségura Jérôme Trouslard Emmanuel Moyse Google Mohamed Najimi Fatiha Chigr Fatima Rachidi Stéphanie Ségura Jérôme Trouslard Emmanuel Moyse Google Scholar Mohamed Najimi Fatiha Chigr Fatima Rachidi Stéphanie Ségura Jérôme Trouslard Emmanuel Moyse PubMed Mohamed Najimi Fatiha Chigr Fatima Rachidi Stéphanie Ségura Jérôme Trouslard Emmanuel Moyse Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.