Abstract
Glucosamine sulfate (GS) is essential for the regeneration of cartilaginous tissue and, in addition, it has anti-inflammatory properties comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical trials indicate the synergism between GS and NSAIDs in osteoarthritis (OA) and other joint diseases. Objective : to estimate the degree of synergism between different combinations of GS and NSAIDs. Material and methods . A differential chemoreactome analysis was employed to evaluate the effects of GS and seven agents from the class of NSAIDs, such as ketorolac, nimesulide, diclofenac, meloxicam, dexketoprofen, celecoxib, and etoricoxib, for estimating the degree of synergism between different combinations of GS and NSAIDs. Results and discussion . Dexketoprofen is shown to enhance most effectively the anti-inflammatory properties of GS as compared to ketorolac that does this to a lesser extent. The drug should be practically used as follows: the most effective combination (GS + dexketoprofen (or GS + ketorolak) is taken at week 1 of treatment for rapid pain elimination; thereafter there may be a combination of GS and NSAIDs, the intake of which is associated with minimal adverse reactions for a longer time. Conclusion . The investigation has shown that the coadministration of GS and NSAIDs is promising in treating joint diseases.
Highlights
Glucosamine sulfate (GS) is essential for the regeneration of cartilaginous tissue and, in addition, it has anti-inflammatory properties comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs)
Clinical trials indicate the synergism between GS and NSAIDs in osteoarthritis (OA) and other joint diseases
A differential chemoreactome analysis was employed to evaluate the effects of GS and seven agents from the class of NSAIDs, such as ketorolac, nimesulide, diclofenac, meloxicam, dexketoprofen, celecoxib, and etoricoxib, for estimating the degree of synergism between different combinations of GS and NSAIDs
Summary
1. Пространственная структура белка-рецептора CD44 и молекулярные механизмы воздействия ГС и ХС на активность ключевого провоспалительного сигнального пути NF-kB. Взаимодействуя с регулятором IκBα, NF-kB не может пере- томный анализ молекулы ГС в сравнении с семью НПВП мещаться в клеточное ядро и активировать экспрессию ге- Молекулярные механизмы синергизма ГС и НПВП в на первом этапе хемоинформационного анализа устанавлитерапии патологии суставов являются основой для разра- вали список наиболее близких к ГС и НПВП химических ботки новых перспективных протоколов лечения с одновре- структур из базы данных PubChem [11]. 2: параметры биологической активности (константы) приведены в соответствии с международной номенклатурой; ошибка (погрешность) значения параметра; КТР – кеторолак; НМС – нимесулид; ДКФ – диклофенак; МЛС – мелоксикам; ДКТП – декскетопрофен; ЦКС – целекоксиб; ЭТКС – эторикоксиб; НЭ – нет эффекта Здесь и в табл. 2: параметры биологической активности (константы) приведены в соответствии с международной номенклатурой; ошибка (погрешность) значения параметра; КТР – кеторолак; НМС – нимесулид; ДКФ – диклофенак; МЛС – мелоксикам; ДКТП – декскетопрофен; ЦКС – целекоксиб; ЭТКС – эторикоксиб; НЭ – нет эффекта
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