Abstract

The relationship between DNA damage, mutations and the initiation and progression of sunlight-induced melanoma has not yet been resolved. Recently, it has become apparent that the etiology of sunlight-induced melanoma is fundamentally different from sunlight-induced carcinoma, although both appear to be dependent on specific photoproducts produced in DNA by ultraviolet radiation (UVR). How DNA photoproducts are involved in the unique etiology of cutaneous malignant melanoma (CMM) compared to other types of skin cancer is central to understanding the nature of this disease and its prevention. Based on our results and published data, we propose a model for melanoma distinct from carcinoma, in which different types of DNA damage contribute to different stages of tumorigenesis.

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