Abstract
The bindings of radioiodinated ω-conotoxin GVIA and [ 3H]-nitrendipine to subcellular fractions of rat brain were examined. The results indicated that ω-conotoxin binding site was mainly present in the mitochondrial fraction, whereas nitrendipine binding site was rich in the mitochondrial but also present in the post-mitchondrial fraction. Fractionation of the mitochondrial fraction on a sucrose density gradient centrifugation showed that the both binding sites were localized in the heavy synaptosomal fraction. These results strongly suggest that the N- and L-type voltage-sensitive calcium channels have different localizations.
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