Abstract
Two gastric cancer cell lines, AKG and GK2, were established from a pleural and an ascitic effusion, respectively. GK2 cells have a pseudodiploid karyotype with an add(6)(q27) chromosome in all metaphases examined. The karyotype of AKG cells is highly rearranged: FISH analysis with painting probes has shown that DNA sequences derived from single chromosomes are scattered on several (as many as eight) markers. In this cell line, the C- MYC and the K- RAS oncogenes are amplified. The organization and the copy number of the C- MYC-amplified units are different from the K- RAS units, suggesting that the two oncogenes were amplified independently. The presence of a few marker chromosomes carrying both C- MYC and K- RAS could be due to translocation events that followed the amplification.
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