Abstract
Platelet-rich plasma (PRP) rich in growth factors has evolved as an important therapy for periodontal tissue regeneration. A healthy blood donors obtained for homologous PRP (h-PRP). The Freeze-drying h-PRP sample provides an effective method to ensure a longer shelf-life. The h-PRP samples are subjected to crossmatch testing in clinics to prevent any immune response in recipients. The present study aimed to evaluate the differences in donor compatibility on crossmatch test results towards fresh and freeze-dried h-PRP (FD h-PRP). This was a laboratory experiment, h-PRP prepared according to the protocol of blood bank, and 40 recipients blood samples divided into two groups, fresh h-PRP (control group) and FD h-PRP. The crossmatch test was performed to evaluate h-PRP compatibilities by using the gel-test method. The data were analyzed using the chi-square test. The results of the study showed that the crossmatch test on FD h-PRP samples was 100 % compatible and could increase the compatibility results of the donor. the FD h-PRP was safe to become donors and clinical applications.
Highlights
Platelet-rich plasma (PRP) is plasma sample rich in platelets, growth factors, chemokines, cytokines and other proteins
The present study aimed to evaluate the differences between donor compatibility on crossmatch test results towards fresh and freeze-dried homologous PRP (h-PRP)
Platelets are characterized by the presence of complex surface antigens, including Human Platelet Alloantigen (HPA), Human Leukocyte Antigen (HLA), and blood group antigen ABO
Summary
Platelet-rich plasma (PRP) is plasma sample rich in platelets, growth factors, chemokines, cytokines and other proteins. It finds wide applications in medical field, especially in dentistry. The use of A-PRP in periodontal tissue regeneration has been reported to show variable treatment outcomes owing to variability in platelet amounts This variability in platelet amounts is generally contributed by various conditions in patients, such as poor medical history, multi-drug therapy, or hematological disorder. The freeze-drying process of h-PRP results in protein reduction, denaturation, and undetectable antibody This reduces the risk of rejection or elicitation of immune response [11]. The present study aimed to evaluate the differences between donor compatibility on crossmatch test results towards fresh and freeze-dried h-PRP
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