Abstract
The components of acidic glycosaminoglycans (AGAG) prepared separately from cortical and medullary tissues of human male kidneys were analyzed by enzymatic methods. Heparan sulfate was the main component, comprising approximately half of total AGAG, and was significantly higher in the cortex than in the medulla. In the cortex, the major AGAG was heparan sulfate (67% of total AGAG) followed by dermatan sulfate (17%). In the medulla, the main AGAG was also heparan sulfate (45%) followed by hyaluronic acid (15%) and chondroitin 4-sulfate (16%). A possible role of the different AGAG composition in the two regions is discussed.
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