Abstract
The measurement of fibrinogen is an important part of a haemostatic investigation and has traditionally been performed in the majority of clinical laboratories using a Clauss fibrinogen method [1]. More recently, automated coagulometers using optical endpoint detection systems have been developed, allowing use of fibrinogen measurements derived from the clotting curve characteristics of the prothrombin time measurement (PTderived fibrinogen). Several reports [2,3] including data from the UK National External Quality Assessment Scheme (NEQAS; Blood Coagulation) EQA exercises demonstrated clinically important differences between Clauss and PT-derived fibrinogen measurements in subgroups of patients and led to a recommendation that the PT-derived method be not used as a primary method for fibrinogen estimation [4].
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