Abstract
The Montreal cognitive assessment (MoCA) is known to discriminate patients with mild cognitive impairment (MCI). Recently cognitive reserve (CR) is introduced to compensate the cognitive decline. We aimed to find out how well MoCA reflects CR and find differences between the MoCA and Mini-mental state examination (MMSE) in reflecting CR. MoCA, MMSE, and Cognitive reserve index questionnaire (CRIq) were administered to 221 healthy participants. Normative data and associated factors of MoCA were determined. Correlation analysis of MoCA and CR was performed and a comparison of MoCA with MMSE in the degree of the reflection of CR was conducted. MoCA reflected CR in education (β=0.252, P<0.001), working (β=0.156, P=0.023) and total CR (β=0.383, P<0.001) while MMSE reflected CR only in education (β=0.299, P<0.001) and total CR (β=0.373, P<0.001). MoCA reflected CR better than MMSE in total score of CR (Z=2.30) and education domain (Z=1.05).
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