Difference Influence of Exercise (Lumbo-Pelvic and Yoga) on Menstrual Low Back Pain in Cases of Early and Late Menarche

Early and late menarche are associated with oligomenorrhea and predict metabolic syndrome 26 years later

To evaluate the psychopathological symptoms, suicide, and self-harming behaviors among students with early, on-time, and late menarche in high school and college and the association of early menarche with these disorders. The design consisted of a cross-sectional study of 5597 high school students and 2768 college students. Menarche age, suboptimal mental health status, anxiety, depression, suicide, and self-harming behaviors were obtained by self-report questionnaire. In high school students, all the disorders occurred at significantly higher frequency in those with early menarche than in those with on-time and late menarche. In college students, only suboptimal mental health status, depression, and suicidal ideation happened at significantly higher frequency in the early menarche group than in the other two groups. The college group had a lower frequency of all the disorders than the high school group for all three groups of girls, that is, with early, on-time, or late menarche. In a multivariate logistic regression model, early menarche persisted as a risk factor for all the disorders after other factors were controlled. Psychopathological symptoms, suicide, and self-harming behaviors are more common in early menarche students than in on-time and late menarche students. The effects of early menarche on the disorders might dissipate over time. Early menarche might serve as a predictor for the disorders in Chinese girls.

The onset of menstruation is a turning point in women's sexual maturity that, unlike other stages of growth, occurs abruptly and is a critical stage in girls' lives. The present study investigated body image and peer relations among girls with early, late, and normal menarche. This casual-comparative descriptive study included female students aged 9-17 in Isfahan. The participants were selected using multistage cluster random sampling. Out of 5,984 students, 56, 37, and 43 were selected for the normal, early, and late menarche groups. The Body Image Concern Inventory and Index of Peer Relations were the two tools used in this study. Moreover, the data were analyzed using a covariance statistical test. Girls with early menarche had better peer relations than those with late menarche (P = 0.01). In addition, there was a significant difference between adolescents with normal and late menarche in terms of body image (P = 0.01). Girls who experienced late menarche were more concerned about their body image and appearance; however, girls with early menarche experienced more impaired performance (P = 0.05). The first menstrual cycle, or menarche, affects psychological variables such as body image and peer relations. The later the menarche, the fewer problems in regard to body image and peer relations.

Studies suggest asthma is associated with body mass index (BMI), pubertal development and hormonal status. We used data collected at ages 7, 11, 16 and 33 from the 1958 British...

Objective To assess the effect of early menarche and treatment with gonadotropin-releasing hormone analogs(GnRHa)in girls with central precocious puberty(CPP)or early and fast puberty(EFP)on menstrual regularity. Methods Six hundred and ten healthy girls were recruited and their menarche age and menstrual cycle were recorded. 169 CPP or EFP girls treated with GnRHa were followed up, and their menarche age and menstrual cycle were also recorded. Results There were 129 girls with irregular menstruation among 610 healthy girls(21.1%), with 10 in 44 early menarche girls(22.7%)and 11 in 44 late menarche girls(25.0%). Compared with normal menarche girls(17.2%), no significant difference was found in the incidences of irregular menstruation in early and late menarche girls. The incidences of dysmenorrhea were 41.1% in normal girls and 50.0% in early menarche girls, without significant difference. There was a higher incidence of irregular menstruation in 113 CPP girls and 56 EFP girls treated with GnRHa compared with healthy girls(31.4% vs 21.1%, P 0.05). Fifty-seven cases treated with GnRHa(33.7%)suffered from dysmenorrhea, and there was no significant difference as compared with healthy girls and girls with early menarche. Conclusion The incidence of irregular menstruation was similar in early menarche girls and normal girls. CPP and EFP girls with GnRHa treatment had a significantly higher incidence of irregular menstruation than normal girls, but no difference was found as compared with girls with early menarche. Early menarche and GnRHa treatment did not affect the incidence of dysmenorrhea. (Chin J Endocrinol Metab, 2015, 31: 774-777) Key words: Early menarche; Central precocious puberty; Early and fast puberty; Gonadotropin-releasing hormone analogs; Menstrual regularity

Is age at menarche associated with fecundability? Both early (<11 years) and late (>15 years) menarche is associated with decreased fecundability. Previous studies on age at menarche and fecundability have been inconclusive. Women with early or late menarche are at increased risks of gynaecological and autoimmune diseases that may affect their ability to conceive. We conducted a retrospective cohort study including 67 613 pregnant women, participating in the Norwegian Mother, Father and Child Cohort Study between 1999 and 2008, with self-reported information on age at menarche and time to pregnancy. We included planned pregnancies that were conceived either naturally or with the help of assisted reproductive technologies. We calculated fecundability ratios (FRs) with 95% CIs representing the cycle-specific probability of conception by categories of age at menarche. FRs were adjusted for participants' pre-pregnancy body mass index, highest completed or ongoing education level, and age at initiation of trying to conceive. We observed a 7% lower probability of conceiving during any given menstrual cycle up to 12 cycles in women with early or late menarche. Among women with menarche >15 years, the adjusted FR was 0.93 (95% CI: 0.90-0.97), and among women with menarche <11 years, the adjusted FR was 0.93 (95% CI: 0.89-0.99), when compared to women with menarche between 12 and 14 years. The study-population consisted of women pregnant in their second trimester, excluding those with persistent infertility. Recall of age at menarche and time to pregnancy may be inaccurate. Both early (<11 years) and late (>15 years) menarche was associated with decreased fecundability. Women experiencing early menarche or late menarche may be counselled accordingly. This study was funded by the Norwegian Institute of Public Health, Oslo, Norway, and by Telemark Hospital Trust, Porsgrunn, Norway and was partly supported by the Research Council of Norway through its centres of excellence funding scheme (project number 262700) and the Research Council of Norway (project no. 320656). The project was co-funded by the European Union (ERC, BIOSFER, 101071773). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. M.C.M. has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement no. 947684). The authors report no competing interests. N/A.

We investigated whether girls experiencing early menarche have an increased risk of depression during young adulthood. This study used data collected in the Growing Up Today Study (N = 9,039), an ongoing prospective cohort of the daughters of women enrolled in the Nurses' Health Study II. After excluding girls who were postmenarcheal at baseline in 1996, <20 or ≥26years old in 2007, or missing data on key covariates, the final sample size was 3,711. Self-reported age at menarche was collected annually. Depressive symptomatology was measured in 2007 using the 10-item Center for Epidemiologic Studies Depression (CES-D-10) score. Sixteen percent of girls (N = 596) reported high levels of depressive symptoms (CES-D-10 ≥ 14) in 2007. Neither early nor late menarche was associated with high depressive symptoms (for early vs. normative menarche, odds ratio (OR) = 1.08, 95% confidence interval (CI) = 0.85-1.38; for late vs. normative menarche, OR = 0.91, 95% CI = 0.70-1.18) or with differences in continuous CES-D-10 score in young adulthood. Although previous studies suggest that girls with early menarche suffer from an increased risk of adolescent depression, this does not appear to persist into young adulthood.

PurposeTo examine the relationship between menarcheal age and anthropometric indices and menstrual irregularity in late adolescent girls in Seoul.MethodsWe surveyed 4,218 fertile adolescent girls between the ages of 16 and 18 years to determine their anthropometric indices and menarcheal age. Measurements were taken from June 2008 to October 2009 at seven girl's high schools in Seoul, Korea. Participants were offered self-report questionnaire as a survey tool that included questions on anthropometric indices (height, weight, waist circumference), menarcheal age, menstrual pattern, frequency of menstruation per year.ResultsThe participants were categorized into three groups based on menarcheal age: early menarche group (younger than 2 standard deviations [SD]), mid menarche group (within ±2 SD), late menarche group (older than 2 SD). The mean age of early menarche group was 9.9±0.2 years, mid menarche group 12.5±0.9 years, late menarche group 15.1±0.3 years (P < 0.001). Heights were recorded as 160.4±5.2 cm, 161.8±4.9 cm, 162.3±4.7 cm in early, mid, and late menarche group, respectively (P = 0.001). Body mass index (BMI) and waist circumference significantly were lager in early menarche group than mid and late menarche ones (P < 0.001). The menarcheal age had a positive correlation with height and negative correlations with weight, BMI, waist circumference (P < 0.001). The prevalence of oligomenorrhea was more frequent in late menarche group than early and mid menarche group.ConclusionThe menarcheal age have positive relationship with height and inverse relationship with BMI and waist circumference in late adolescent girls in Seoul. Late menarcheal girls are disposed to have menstrual irregularity compared to early menarcheal girls.

Background: Menarche, the onset of the female menstruation, is a marker of pubertal timing. Age at menarche varies widely between girls and is highly dependent on nutritional status and body fat accumulation. The occurrence of menarche at an early age is linked to an increased risk of several adverse health conditions later in life, such as obesity, type-2 diabetes, breast and endometrial cancer, and cardiovascular disease. Indeed, for every one year decrease in age at menarche (from an average age at menarche of 12.5 years), breast cancer risk is increased by 5%. Several genome wide association studies (GWAS) have identified genetic variants (i.e. in the LIN28B gene) that are associated with early age at menarche, however little is known about the changes occurring in the breast tissue of women with early menarche. We hypothesize that early age at menarche results in permanent molecular alterations in the breast tissue and that those abnormalities may contribute to the tissue’s susceptibility to carcinogens and breast cancer development. Methods: To test our hypothesis we used the resources available at the Susan G. Komen Tissue Bank at the Indiana University Simon Cancer Center (KTB). We selected histologically normal breast tissue from healthy, young women with either early (age ≤ 10 years) or late menarche (age ≥ 15 years), and matched for age, race, BMI, and menstrual phase. Breast tissue biopsies from these women were microdissected to isolate the breast epithelium and next generation RNA-sequencing was used to generate a transcriptome profile for each sample. Differential expression was performed using DESeq2 in R. The tissue samples were also evaluated using immunostaining. Results/Conclusions: Preliminary data show significant differences when comparing the transcriptome profiles of the microdissected breast epithelium from the early and late menarche sample cohorts. The tissue from women with early menarche had upregulation of genes associated with defense against oxidative stress and/or infectious bacteria (lactotransferrin [LTF], ceruloplasmin [CP]), cell adhesion, (ITGα11, ITGαX, ITGαM, ITGαL, ITGβ2), immune response (CARD9, LAIR1), and had downregulation of ubiquitination pathways (USP40, AMFR) and lipoprotein metabolism (OSBPL1A, LIPH, PIGN). Immunohistochemical evaluation of markers of oxidative stress (LTF, CP), cell proliferation (Ki67), and immune infiltrates (CD45, CD20, CD8, CD68) is underway. Together, this information will give us the opportunity to better understand early age at menarche as a breast cancer risk factor and advance research for women’s health. Citation Format: Mariah L. Johnson, Natascia Marino, Anna Maria V. Storniolo, Bradley A. Hancock, Milan Radovich, George E. Sandusky. Molecular alterations in the breast associated with early menarche [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4250. doi:10.1158/1538-7445.AM2017-4250

Age at menarche may influence the onset of depression later in life. We aim to assess the association between early/late menarche and depressive outcomes in females by updating a systematic review and meta-analysis. The search of the original systematic review was updated for studies published in PubMed, Embase, and Cochrane Library from 2013 to 2023. The early/late and on-time menarche divisions were generally based on each study. Depression or depressive symptoms could be measured through various validated tools and diagnostic criteria. We assessed the quality of the evidence using the GRADE approach and performed a random-effect meta-analysis with age at menarche and the cases of depression as outcomes. We included eight cohort and three cross-sectional studies (138,819 participants). Females with early menarche were more likely to have depression later in life compared with those who had on-time menarche (early vs. on-time menarche: odds ratio (OR) = 1.11; 95% confidence interval (CI): 1.03, 1.20; I2 = 44.5%). We found a null association between late menarche and depression for females (late vs. on-time menarche: odds ratio (OR) = 1.00; 95% confidence interval (CI): 0.87, 1.15; I2 = 73.2%). Sensitivity analyses showed that the results were robust. The quality of the available evidence was rated as very low. Existing evidence suggests that early menarche may be associated with an increased risk of depression in females. But it remains unclear about late menarche. More high-quality studies are warranted.

The relationship of early and late menarche with adult body dimensions has been studied on a sample of 147 young adult women drawn from an urban Punjabi population of Chandigarh and Ludhiana. The results indicate that girls with early menarche (age 10 to 11) have significantly smaller skeletal dimensions (both longitudinal and transverse) and more subcutaneous fat than those with average or late menarche. The girls with late menarche have on average more height for weight than early maturers. Results indicate that there is a biological determinant of the observed association between menarcheal age and fatness and adult body size.

Early menarche was associated with an increased risk of MetS and IR in premenopausal Korean women. Early menarche is associated with higher risk of CVD-related death and all-cause mortality in Western studies. Early menarche is associated with higher risk of diabetes in Korean premenopausal women. Early menarche (<12 years) is associated with metabolic syndrome and insulin resistance in nationally representative Korean premenopausal women. However, late menarche (>16 years) is not associated with metabolic syndrome after controlling for age and other confounders.

BackgroundBipolar disorder (BD) is related to reproductive cycles. However, findings on putative correlation between age at menarche and course of BD are particularly scarce and conflicting. The aim of the present study is to analyze the relationship between age at menarche and characteristics of BD, including comorbid medical conditions and peripartum mood episodes.MethodsThe study sample consists of 288 women with BD type I, II, or not otherwise specified (NOS). Age at menarche was both considered as a continuous variable and categorized into three groups: early menarche (≤11 years), normal menarche (12–14 years), and late menarche (≥15 years). The study focused on two sets of comparisons, by age at menarche and women with vs. without children. Spearman correlation matrix was produced to calculate correlations between the variables of interest. Socio-demographic and clinical characteristics between early, normal and late menarche, and women with vs. without children were examined through descriptive statistics. Finally, adjusted logistic regression analysis was run to examine the association between variables.ResultsOut of 288 women included in the study, 21.5% had early menarche, 55.6% had normal, and 22.9% had late menarche. Women with early menarche had higher rates of metabolic syndrome compared to women with normal menarche even after adjustment for age. The subgroup of women with children does not present clinical differences compared to women without children except a lower rate of psychiatric comorbidities. At least one mood episode with peripartum onset occurred in 29.6% of the women with children. After controlling for confounding variables, women with late menarche were associated with lower probability of BD peripartum episodes compared to women with normal menarche.ConclusionAge at menarche may be related to specific characteristics of women with BD. The results deserve to be deepened in further studies.

Purpose To assess the association between abnormal timing of menarche among adolescent girls and neighbourhood socioeconomic status of their school area. Materials and methods Our analysis included 187,024 girls aged 15–18 years from the Korea Youth Risk Behaviour Web-Based Survey (KYRBS) from 2007 to 2015. Early and late menarche were defined as menarche before 11 years and no menarche by age 14 years, respectively. The deprivation index values for the areas where the schools were located were used as an indicator of neighbourhood socioeconomic status based on the 2005 national census data. We calculated odds ratios (OR) for early and late menarche using a multinomial logistic regression model. Covariates included body mass index, parental education, single or stepparents, siblings, household wealth, year of birth, survey year, and urbanisation. Results Mean age at menarche was 12 years. The overall proportions of early and late menarche were 11.3% and 3.3%, respectively. When divided into four quartile groups based on the socioeconomic deprivation index, 11.3% of girls in the most deprived quartile and 10.6% in the least deprived area showed early menarche. The prevalence of late menarche did not differ across the deprivation index quartiles of school area. Attendance at schools located in highly deprived areas was associated with up to 10% higher risk of early menarche. This positive association was not evident for late menarche. Conclusion Among contemporary Korean girls, socioeconomic deprivation of the school area was associated with earlier puberty. This finding highlights the potential role of the socioeconomic environment of schools in women’s lifetime health.

Height and age at menarche demonstrate plasticity in response to social, environmental, and economic factors. Since the end of the 20th century, there has been a noticeable increase in height and a decrease in the age of maturation due to changing living conditions. While a relation between height and age at menarche is widely accepted, the extent of this relationship and the specific conditions that exert the greatest influence remain unclear. This study examines the relationship between age at menarche and final height in women who grew up under varying socio-economic conditions, with particular attention to those exposed to heavy workloads during childhood. The recall method was employed to gather data from 304 women aged 20-45 years regarding their age at menarche. 10 participants who could not recall their age at menarche were excluded, leaving a final sample of 294 women. To assess the impact of age at menarche on height, the distribution of menarcheal ages in the sample was analyzed, and participants were categorized into early (9-11 yrs), normal (12-14 yrs), and late (15-18 yrs) menarche groups. The mean height and menarcheal age for the sample were as follows: 1591.5 (±61.01) mm and 12.68 years (±1.36) for the upper socio-economic group; 1562.7 (±55.2) mm and 13.28 years (±1.45) for the lower socio-economic light worker group and 1543.2 (±62.5) mm and 13.36 years (±1.39) for the lower socio-economic heavy worker group. Significant differences were found across all variables (p < 0.010). Women with early menarche were shorter, and those with late menarche were taller, a trend that was consistent across both advantaged and disadvantaged conditions. This confirms the relationship between age at menarche and height. However, despite the influence of menarcheal age, differences in final height were more strongly associated with socio-economic factors. Consequently, the findings indicate that height demonstrates considerable plasticity in relation to socio-economic conditions and the demands of heavy physical labor.