Difference in sensory dependence of occ1/ Follistatin-related protein expression between macaques and mice

Abstract

occ1/ Follistatin-related protein ( Frp) is strongly expressed in the primary visual cortex (V1) of macaque monkeys, and its expression is strongly down-regulated by intraocular tetrodotoxin (TTX) injection. The pronounced area selectivity of occ1/ Frp mRNA expression occurs in macaques and marmosets, but not in mice, rabbits and ferrets, suggesting that occ1/ Frp is an important clue to the evolution of the primate cerebral cortex. To further determine species differences, we examined the sensory-input dependency of occ1/ Frp mRNA expression in mice in comparison with macaque V1. In macaque V1, occ1/ Frp mRNA expression level significantly decreased with even 1-day monocular deprivation (MD) by TTX injection. In contrast to that in macaques, however, the occ1/ Frp mRNA expression in the visual cortex in mice was not down-regulated by 1- to 7-day MD by TTX injection. Similarly, MD had no effect on occ1/ Frp mRNA expression level in the dorsal lateral geniculate nucleus of mice. In addition, the extirpation of the cochlear or olfactory epithelium had no effect on occ1/ Frp mRNA expression in either the cochlear nucleus or the olfactory bulb in mice. Thus, occ1/ Frp mRNA expression is independent of sensory-input in mice. The results suggest that activity-dependent occ1/ Frp mRNA expression is not common between mice and monkeys, and that primate V1 has acquired a unique gene regulatory mechanism that enables a rapid response to environmental changes. The characteristic feature of the activity dependency of occ1/ Frp mRNA expression is discussed, in comparison with that of the expression of the immediate-early genes, c-fos and zif268.