Abstract
Dietary restriction (DR) from weaning or young adult stages in laboratory animals throughout their usual life span extends maximum lifespan and retards the development of a broad spectrum of pathophysiological changes. However, the effects of DR when performed at middle age or later have not been well investigated. We previously reported that short‐term (about 2.5 months) DR in early senescence reduced the amount of altered proteins and shortened the half‐life of proteins. Furthermore, our previous studies in rats demonstrated DR initiated later in life reduces the content of oxidatively modified proteins, measured as protein carbonyls, in mitochondria from old rats. In addition, we recently found that the age‐related decline in the activities of proteasomes that have been implicated in removal of altered proteins was restored by DR. Thus, our findings suggest that DR initiated even relatively late in life can restore an animal's youthful condition, reducing the accumulation of altered proteins.
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