Abstract
AbstractThis study was intended to examine the effects of navel orange (Citrus sinensis (L.) Osbeck) essential oil (OEO) on depression in the reserpine‐treated mice. And the chemical composition of OEO was analysed by gas chromatography (GC) analysis. The results indicated that the major compounds of OEO were terpenes. And OEO treatment produced an antidepressant‐like effect in mice, as indicated by the increased locomotor activity in the open field test (OFT) and attenuated dyslipidemia, but it had no effect on duration of immobility in the forced swim test (FST). Dietary OEO counteracted the reserpine‐induced hypothermia and palpebral ptosis. Moreover, OEO treatment increased the levels of serotonin (5‐HT) and dopamine (DA) in the mice brain. These antidepressant‐like effects of OEO are essentially similar to the effects of the antidepressant fluoxetine. And the action of OEO may be mediated by the central serotonergic and dopaminergic systems.
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