Abstract
Polymeric micelles, self-assemblies of block copolymers, are emerging as attractive drug delivery systems for hydrophobic photodynamic sensitizers. Recent advances in the formulation of photosensitizers for photodynamic therapy (PDT) with diblock copolymers are presented. This paper reviews the main characteristics of existing drug-loading micelles with diblock copolymers, including loading efficiency, particle size and morphology, stability, cellular uptake, subcellular distribution and therapeutic efficiency. The results indicate that diblock polymeric micelles are potentially useful for the delivery and release of hydrophobic photosensitizers in PDT. While significant progress has been achieved, many challenges remain in elucidating the detailed internalization mechanisms of the micelles and resulting mechanisms for enhanced photocytotoxicity. Some critical issues for diblock copolymers to deliver hydrophobic photosensitizers for PDT are highlighted.
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