Abstract
AbstractThe asymmetric synthesis of the lichen macrolide (+)‐aspicilin (1) was realised in 19 steps and with high stereoselectivity (de ≥ 91 %, ee ≥ 96%). Three of the four stereogenic centres were generated by employing the SAMP/RAMP hydrazone method. Key steps of the synthesis are the α,α′‐double alkylation of RAMP hydrazone (R)‐10 of 2,2‐dimethyl‐1,3‐dioxan‐5‐one B and the enantioselective synthesis of the bromo alcohol (S)‐9 (subunit A) by a combination of SAMP hydrazone α‐alkylation with subsequent Baeyer‐Villiger oxidation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
