Diagnostic Utility of Platelet - Lymphocyte Ratio in Adults with Sepsis: A Case - Control Study

Abstract

Background The platelet-lymphocyte ratio PLR a novel inflammatory marker may act as an indicator of inflammation and also the severity of the sepsis in patients. Objective We investigated the diagnostic utility of PLR in sepsis in adults by calculating the PLR in culturepositive and negative groups as no studies have been conducted in this regard.Materials and Methods Retrospectively adult patients gt18 years clinically diagnosed with sepsis and who had undergone blood culture analysis were included. The patients with a negative culture were considered as the control group. Patients with malignancy autoimmune diseases chronic inflammatory diseases congenital heart disease and concomitant illnesses like malaria dengue or any other viral fever which could alter the PLR and those who were on antiplatelet drugs or had undergone antibiotic therapy previously were excluded. The platelet and absolute lymphocyte counts on the day of admission were used for the calculation of PLR. Each group comprised 76 n76 patients. Statistical analysis was done by using the mean standard deviation and t-test.Results The PLR between the two groups showed a mean difference with a P value of 0.148 which was not statistically significant.Conclusion Although there was a difference in the PLR between the 2 groups it was not statistically significant. Further studies with a bigger sample size and a prospective approach will help in further establishing the diagnostic utility of PLR in sepsis.nbsp