Abstract
The aim of this study was to determine the histopathological lesions associated with Encephalitozoon cuniculi (E. cuniculi) infection in 25 New Zealand rabbits randomly selected in a laboratory animal center. Microscopic lesions were evaluated on sample slides stained with HE, Gram, and Immunohistochemistry (IHC) techniques. Mild and moderate lesions included granulomatous inflammation, meningitis, and perivascular cuffing were identified in brain samples; interstitial nephritis and renal fibrosis were identified in the kidneys of 21 out of 25 rabbits. Among the 21 rabbits, the percentage of spore identification by HE and Gram staining methods were 9.5% and 71%, respectively while IHC revealed parasite antibody in 81% of the rabbits. Thus, laboratory New Zealand rabbits in Vietnam might be infected with high prevalence of E. cuniculi. Postmortem diagnosis with HE technique can be used for screening [i]while Gram and IHC staining can confirm the infections. The rabbit husbandry units should consider appropriate methods for infection assessment and control.
 
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