Abstract
ABSTRACT The eosinophilic granuloma is the most common form of the Langherans’ cell histiocytosis. In the majority of cases it is represented by a unilocular osteolytic lesion which can occur in adults and children. It is an intraosseous destructive lesion characterized by the presence of vast numbers of eosinophils and histiocytes. It can be localized or multifocal. The tumor is more prevalent in the first two decades of life and tends to affect mandibular body and angle. Most frequent signs and symptoms are pain, swelling, ulceration, gingival necrosis, alveolar bone destruction with mobility and loss of teeth. Therapeutic interventions for this pathology are surgical curettage, local radiotherapy and chemotherapy. This article presents the case of a 9-year old patient who came in for treatment with facial swelling, pain, tooth mobility and intraoral ulcer in the vestibular sulcus of the right mandibular angle region. Imaging and incisional biopsy were obtained. After the histopathological examination confirmed the diagnosis of eosinophilic granuloma, the lesion was removed by curettage and a reconstruction titanium plate was inserted to avoid a pathological fracture. After 14 years of follow-up no recurrence was found and mandibular growth was not impaired. A discussion about this type of tumor is presented, based on the current literature.
Highlights
Eosinophilic granuloma (EG) is the mildest form of the disease of Langerhans’ cell Histiocytosis [1]
Depending on the bone destruction of the maxillae, it may lead to pathological fractures [3,7]
Extensive involvement of the alveolar bone may result in the appearance of teeth “floating in the air” [1,6,8]. In these cases teeth may be observed with the presence of mobility and deep periodontal pockets, mucosa with ulcerative or proliferative lesions, with erythema and severe tendency to bleeding on probing [7]. These clinical and radiographic characteristics resemble those of aggressive periodontal diseases [1,2,4,5], and it is important to perform differential diagnosis by means of specific clinical findings, evolution of the pathology and biopsy for histopathological exam
Summary
Eosinophilic (monostotic or polystotic) granuloma (EG) is the mildest form of the disease of Langerhans’ cell Histiocytosis [1]. Extensive involvement of the alveolar bone may result in the appearance of teeth “floating in the air” [1,6,8] In these cases teeth may be observed with the presence of mobility and deep periodontal pockets, mucosa with ulcerative or proliferative lesions, with erythema and severe tendency to bleeding on probing [7]. These clinical and radiographic characteristics resemble those of aggressive periodontal diseases [1,2,4,5], and it is important to perform differential diagnosis by means of specific clinical findings, evolution of the pathology and biopsy for histopathological exam
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
