Abstract
As part of a large study evaluating the developmental toxicology of industrial alcohols, groups of approximately 15 Sprague-Dawley rats were exposed for 7 h/day on gestation days 1–19 to one of three alcohols at the highest concentrations we could generate as a vapor. Since these concentrations were not sufficiently high to be toxic to the maternal rats, lower levels were not included. These concentrations were 14,000, 3500, and 850 mg/m3 1-pentanol, 1-hexanol, and 2-ethyl-1-hexanol, respectively. Dams were weighed daily for the first week of exposure and weekly thereafter and were sacrificed on day 20. Fetuses were serially removed, blotted dry, examined for external malformations, sexed, weighed, fixed, and examined for visceral or skeletal defects. Pentanol reduced maternal feed intake and weight gain, but there were no significant decreases in fetal weights. Resorptions were slightly increased in the group exposed to 1-hexanol, and 2-ethyl-1-hexanol reduced maternal feed intake, but neither hexanol derivative produced malformations. Obviously, teratogenicity by other routes of exposure cannot be ruled out, particularly in view of the low volatility of these alcohols. However, the present studies indicate that inhalation of pentanol, hexanol, or 2-ethyl-1-hexanol at the stated concentrations can produce limited maternal toxicity, but none was teratogenic to rats.
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