Abstract
The thyroid hormone receptor α gene is alternatively spliced to give the α receptor and a variant which does not bind thyroid hormones. An additional alpha-like receptor (Rev-erbAα) is transcribed on the opposite strand and overlaps the unique variant sequence. The α receptor in rat brain reaches peak levels 5–15 days after birth. The variant remains high from 2 days before birth to old age. The Rev-erbAα mRNA increases beginning 5 days after birth, maximizing in adulthood. Thyroid hormone decreases and hypothyroidism increases the level of these 3 messages. We conclude that the levels of these messages are similarly controlled by thyroid hormone but have different ontogenetic controls. No functional results can be seen in vivo from potential anti sense pairing of Rev-erbA α with the variant.
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