Abstract
(1) By growing Streptococcus jaecalis (ATCC No. 8043) in a medium containing successively higher concentrations of amethopterin, more than a thousand-fold increase in resistance has been achieved. (2) This amethopterin-fast variant has a slightly lower requirement for folic acid in the absence of amethopterin than the parent sensitive strain. In the absence of folic acid, however, amethopterin and certain other 4-amino derivatives of PGA can replace this folic acid requirement in the resistant strain.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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