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Abstract
Many Lactobacillus and Lactococcus strains aregenerally regarded as safe for consumption because they are utilized for food fermentationor inhabit the intestinal mucosa as commensals. Recently, vaccine delivery systems usinglactic acid bacteria (LAB) have been under development. Our research group has beeninvestigating the development of oral mucosal vaccines against Salmonellaenterica serovar Enteritidis (SE) using Lactobacillus caseiIGM393 as an antigen delivery vehicle. Recombinant lactobacilli expressing SE antigens,FliC, SipC, and OmpC, have been constructed and orally administered to mice. Antigenspecific immune responses and protective immunity were elicited after the immunization.For adjuvant-delivery, IL-1β-secreting L. casei was also engineered andits effects evaluated in vitro and in vivo. This articlereviews a novel approach to the elimination of Salmonella via thedevelopment of a vaccine in lactobacilli.
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