Development of Prediction Models for Unplanned Hospital Readmission within 30 Days Based on Common Data Model: A Feasibility Study.

Abstract

Background Unplanned hospital readmission after discharge reflects low satisfaction and reliability in care and the possibility of potential medical accidents, and is thus indicative of the quality of patient care and the appropriateness of discharge plans. Objectives The purpose of this study was to develop and validate prediction models for all-cause unplanned hospital readmissions within 30 days of discharge, based on a common data model (CDM), which can be applied to multiple institutions for efficient readmission management. Methods Retrospective patient-level prediction models were developed based on clinical data of two tertiary general university hospitals converted into a CDM developed by Observational Medical Outcomes Partnership. Machine learning classification models based on the LASSO logistic regression model, decision tree, AdaBoost, random forest, and gradient boosting machine (GBM) were developed and tested by manipulating a set of CDM variables. An internal 10-fold cross-validation was performed on the target data of the model. To examine its transportability, the model was externally validated. Verification indicators helped evaluate the model performance based on the values of area under the curve (AUC). Results Based on the time interval for outcome prediction, it was confirmed that the prediction model targeting the variables obtained within 30 days of discharge was the most efficient (AUC of 82.75). The external validation showed that the model is transferable, with the combination of various clinical covariates. Above all, the prediction model based on the GBM showed the highest AUC performance of 84.14 ± 0.015 for the Seoul National University Hospital cohort, yielding in 78.33 in external validation. Conclusions This study showed that readmission prediction models developed using machine-learning techniques and CDM can be a useful tool to compare two hospitals in terms of patient-data features.