Abstract
9694 Background: We have developed a multi-channel RF interstitial hyperthermia system compatible with the high-dose rate Iridium-192 remote after loading system (Ir-192 RALS). The purpose of this presentation is to evaluate the heating characteristics of the system. Methods: The system is composed of eight channel RF signal generators, which can be controlled individually. Each RF generator consists of two types of electrodes: 1) an internal electrode made of stainless steel, which is originally an Ir-192 RALS applicator; and 2) a shared rectangular external electrode made of copper plate. For the computer simulation, we used simulation software (e-m CAD system, MAFIA ver. 3.20, CST, Germany) to calculate RF field distribution, magnetic field distribution and the specific absorption rate (SAR) distribution, in an arrangement using 4 needles inserted in a square-like formation, 2cm in distance from one another. For the experiments using the agar phantom, we generated a 5W 13.56 MHz RF signal for 5 minutes for 4 electrodes in the same square fashion. Results: The results from the computer simulation showed that SAR distribution outside each electrode was elevated, but the area inside the 4 electrodes did not show temperature elevation. The results from the experiments using the agar phantom showed a temperature increase in the center of the area surrounded by the 4 electrodes. Conclusions: Using an independently controlled RF signal, the results from the experiments with the agar phantom showed satisfactory temperature rise. The RF interstitial system we developed can provide greater heating volume compared to using a single internal electrode or multiple electrodes with a single generator. In addition, our system is compatible with the Ir-192 RALS, allowing for less-invasive interstitial hyperthermoradiotherapy by eliminating the trauma of needle re-insertion. No significant financial relationships to disclose.
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