Development of innovative technologies and creation of modern infrastructure for sustainable development of South Kazakhstan region

The development of innovative information technologies in the modern world has become a necessity for improving the efficiency of activities of financial institutions and improving the quality of financial services provided to economic agents. The State plays an important role in creating a favorable environment for the implementation of such technologies. However, the introduction of innovative technologies by financial institutions is associated with risks that require the State-based regulation to ensure the stability and reliability of functioning of a financial system. The article discusses the issues of improving the State-based regulation of the processes of development and introduction of information and innovative technologies by financial institutions in Ukraine. Particular attention is paid to the substantiation of the need for such regulation. It is determined that the construction of a model of such regulation should be based on the balance of interests of financial institutions, their desire to implement digital technologies for their own development, on the one hand and, on the other hand, their clients, who want to be sure that their personalized information will not be made public to third parties thus leading to a loss of financial resources. The article fragmentarily analyzes the current trends in the development of banking and non-bank financial institutions, describes the transformation processes that have taken place in the model of the State-based regulation of financial institutions in Ukraine. As a result, taking into account the current objective processes of digitalization of both the activities of financial institutions and public authorities that regulate them, measures for the formation and ensuring the effectiveness of the State-based regulation on the introduction of information and communication technologies by financial institutions are proposed, namely: creation of a transparent and open regulatory environment; ensuring a high level of cybersecurity and protection of the customers’ personal data; promoting active cooperation between the State-based regulators, financial institutions, and public organizations for the development and implementation of innovative solutions in the field of balanced use of such technologies.

The mechanism of ensuring the development of health facilities of JSC Ukrzaliznytsya has been described in the article, the author's definition of the concept of the mechanism of development has been provided. The mechanism for ensuring the development of health care facilities is based on the allocation of target, production, innovation, financial and information subsystems. It is determined that the mechanism of ensuring the development of health care facilities is influenced by information flows from the external environment of the enterprise and internal factors, due to the level of development of the strategic potential of the institution. The target subsystem for the development of health care facilities includes strategic goals, objectives, basic criteria for assessing the capacity of the institution, and principles. The production subsystem is directly responsible for the development of healthcare facilities through the implementation of a development strategy, a set of measures to improve the efficiency of operations. The innovation subsystem is represented by a set of tools that facilitate innovation. The main task of the financial subsystem is to ensure the process of development of financial resources. The main task of the information subsystem is to provide the process of development, development and implementation of innovative medical technologies with the necessary reliable information. Key tools for development are identified by the Medical Technology Center, the Development Investment Fund, and the Virtual Health Center. An important tool for ensuring the proper level of development of health care institutions is the organization of a health - a certain Internet space, which, on the one hand, will provide opportunities for different categories of participants of the medical and diagnostic process of all health care facilities Ukrzaliznytsia, on the other hand, will provide all participants of innovation processes with the necessary information on the introduction of innovative technologies. The basic goals, tasks, peculiarities of functioning of the virtual health center in the aspect of providing the medical-diagnostic process and in the aspect of providing the process of creating a closed cycle of development and introduction of innovative medical technologies are revealed.

These effects and intensification factors look different in different sectors of the Russian economy. Accordingly, we can distinguish those that have the lowest values of indicators of innovation development. For them, the measures to intensify the innovative activities of its economic agents are most relevant. The article presents the results of statistical analysis of parameters of development and introduction of innovative technologies. The article is based on the analysis of statistical parameters of development and introduction of innovative technologies. Form 1-Technology became the basis for this analysis. It presents data on so-called «advanced production technologies», managed «by computer», based on «microelectronics and /or the use of digital technologies». By a group of selected industries for the period 2020-2021. the authors conducted an analysis of the effects of the introduction of technologies and obstacles to their implementation. Keywords: innovation, innovative technologies, technology transfer.

The ecological and environmental subsystem is a core link in the regional sustainable development system and an important path for regional green transformation. From data availability, this paper selects 30 provinces and autonomous regions in China (excluding Tibet, Hong Kong, Macao, and Taiwan) from 2005 to 2022 and adopts the system Generalized Method of Moments (GMM) to explore the impacts of green financial policies and urban renewal policies on regional environmental sustainable development, expecting to provide theoretical reference for China's environmentally sustainable development and dual-carbon goal, and draws the conclusions as follows: (1) Overall, green financial development is conducive to regional environmental sustainable development; from a regional perspective, green finance significantly contributes to environmental sustainability in the eastern region, but not in the central and western regions. (2) Urban renewal can improve environmentally sustainable development at the national level, and the implementation of urban renewal policies in the east and central can also improve environmentally sustainable development, but it does not have a significant impact in the west of the country, which is still insufficient to play a positive role. (3) Economic development can promote environmental sustainability, but is not significant in the west. Resource consumption in all regions has a significant inhibitory effect on ecological and environmental sustainability; the increase of the proportion of the secondary industry has a significant inhibitory effect on ecological and environmental sustainability, except for the eastern region; environmental regulation on regional environmental sustainability at the national level and the eastern region can promote environmental sustainability, while the central and western environmental sustainability the greater the negative effect.

The article is investigated the theoretical aspects of innovation in the hotel and restaurant industry. The scientific analysis of concepts and categories «innovation», «novation» is carried out. It is proved that the introduction of innovative technologies is an essential condition for increasing the competitiveness of the hotel and restaurant business. The experience of innovative activity of the hotel and restaurant enterprise on the example of the Turkish hotel “Pacco Boutique Hotel” is considered. It was found that the hotel management pays the most attention to product and process innovations. With the help of SWOT-analysis identified strengths and weaknesses, possible ways to increase the competitiveness of the enterprise. The main weaknesses of the company are - insufficiently qualified staff, low percentage of external financing and insufficient marketing campaign. The influence of external factors, especially technological, on the formation of enterprise competitiveness by means of PEST-analysis is investigated. It clearly shows that the company follows modern trends as far as its financial capabilities. As the hotel uses a protective innovation strategy, first the experience of the leaders of the hospitality industry market is analyzed, and only then the innovations that have already successfully proven themselves are implemented. The main shortcomings in the innovative activity of the hotel and restaurant enterprise “Pacco Boutique Hotel” have been revealed. The management mainly focuses on the development of technological innovations – product and process, but does not pay due attention to organizational and managerial. Insufficiently qualified service personnel, lack of proper control over the quality of service provision, lack of trainings and training systems, advanced training. Such significant shortcomings of the enterprise can lead to loss of competitive positions, trust of visitors. Practical recommendations for improving and implementing innovative technologies in the enterprise to increase competitiveness are offered. The main proposals are the introduction of the latest methods of training and retraining of staff, an innovative method of quality management and competitiveness – benchmarking, as well as an enhanced marketing strategy on social networks on platforms such as Instagram and Facebook.

Nowadays, when the world economies are not yet completely released from the destructive effects of the last global financial crisis and still are feeling intensely the shocks caused by daily economic events, the dilemma arises whether humanity as a whole has a satisfactory quality of life, or whether it lives within dignified human existence. This dilemma is particularly present in small emerging economies, with a special focus on transitional economies, which are still at the beginning of a bumpy road to economic development and prosperity.In recent years, the issue of quality of life has become quite an interesting topic and has been the subject of research in the fields of economics, psychology, clinical medicine, health care, philosophy and sociological sciences. Understanding and evaluating this concept has gone through a long period of evolution. Over the years, the term of quality of life, standard of living, and welfare have been perceived as identical terms, even today their connection is so strong that it is almost impossible to talk about one term without mentioning the others.The question of the quality of human life is an inexhaustible source, so, that is, the inspiration of numerous scientists from all fields of science, with a particular emphasis on economists. To perceive or measure the quality of human life is a complex problem that can never be completely exhausted or clarified with certainty. This is due to the fact that the term "quality of life" itself has a multidimensional character and it is extremely difficult to find all the indicators that would explain this concept and determine its true value.Therefore, the goal of this paper is to analyze certain economic indicators that will enable us to make an adequate assessment, or measure the quality of life. The main emphasis of the paper is on the evaluation of relevant indicators of quality of life in North Macedonia and based on comparative analysis has been concluded that our country is positioned on the lower margins of dignified and quality life. Because of this situation, certain measures have been taken, in order to identify the most important strategic priorities of our country. The realization of these strategic priorities and the appropriate allocation of budget funds will ensure higher growth rates of the Macedonian economy in the coming period, with simultaneous improving of the quality of life and living standard of the population.

For the fifth year in a row, the international symposium SMART LION (Science Medicine Arts Research Translational Lviv International Opportunity Network) is taking place in Lviv, which has become a good tradition in scientific and practical communication. This year, the symposium is focused on the “Medical Imagining and Global Health”. The scientific event was held in Lviv on October 7–9, 2021. The format was mixed. The event was held with the support of Danylo Halytsky Lviv National Medical University, Medical Commission of the Shevchenko Scientific Society, Lviv City Council and Lviv Convention Bureau. The symposium was focused on providing a unique opportunity for young and experienced scientists and doctors working on the development of innovative technologies in medicine, to further cooperate in the field of science and integrate their knowledge and achievements into world science. The interesting and eventful agenda included over 20 lectures and poster presentations delivered by national and foreign lecturers, as well as a master class on “How to use the online Open Journal System to publish scientific articles in medical journals”. To focus the attention of young scientists, students and interns on topical issues of medicine, well-known scientists from different countries of Europe and America are annually invited to attend the symposium as speakers. During the two days of the conference, Ukrainian and foreign leading experts in the field of medicine – Leo Wolansky (USA), Sandor Szabo (USA), Vassyl Lonchyna (USA), Klaus Holzmann (Austria), Siegfried Knasmüller (Austria), Armen Gasparyan (Great Britain), Ivan Wolansky (USA), Yuriy Ivaniv (Ukraine), Nelya Oryshchyn (Ukraine), Andriy Netliukh (Ukraine), Yuriy Mylyan (Ukraine), Oksana Zayachkivska (Ukraine), Roman Plyatsko (Ukraine), Khrystyna Lishchuk-Yakymovych (Ukraine), Olena Zimba (Ukraine) – shared their experience and the latest achievements in the field of medicine. After a two-year break due to a COVID-19 pandemic, joint live discussions between young scientists – students, interns, post-graduate students – with leading scientists during poster presentations and panel discussions held at the symposium helped them rethink the need for systemic changes in medical education and the implementation of modern diagnostic methods utilizing real-time visualization with elements of artificial intelligence into curriculums. In conclusion, Oksana Zayachkivska (Professor, Chair of the Department of Normal Physiology, Danylo Halytsky Lviv National Medical University; Editor-in-Chief of the “Proceeding of the Shevchenko Scientific Society. Medical Sciences”) and Vassyl Lonchyna (Professor, University of Chicago Pritzker School of Medicine, Ukrainian Catholic University) summed up the symposium and expressed hope to meet again at SMART LION 2022.

Current climate risks, increasing urbanization, decreasing availability of arable land for food production, and the risk of flooding can be seen as potential risks to future global food security. The increase in the global population is yet another challenge facing humanity in the twenty-first century. Urgent steps should be taken to pursue a sustainable agricultural policy and achieve food security, including the cluster policy. Clusters are created to enhance efficiency, competitiveness, environmental sustainability, and enterprise development. A model of linkages between the academia, industry, government, and citizens should be implemented to achieve this goal. Cooperation between clusters and farmers is key to implementing innovative business solutions for smart specialization and sustainable development of regions, to provide modern support solutions for efficient management in agricultural production, implement environmentally friendly technologies, and foster innovation. The aim of this study was to develop a conceptual framework for enhanced cooperation between farmers and clusters and to survey Polish farmers’ and experts’ perceptions of the benefits and barriers to such collaboration. The final result was a set of competences for cooperation between farmers and clusters, including the specification of agro-clusters. Farmers should have the opportunity to cooperate with agricultural enterprises to implement innovations, improve the efficiency of agricultural production, improve their skills through training, and foster the growth of farms through cluster activities. The present research is a case study of Poland which is one of the largest food producers in the European Union. The research assumptions were validated by analyzing the existing agricultural clusters in Europe and Poland based on a review of the literature, reports, interviews with experts in agriculture, and rural area development, as well as direct research involving small farms (with an area of less than 20 ha). The foundation of the Sustainable Development Goals (SDGs) is blueprint for peace and prosperity for people and the planet, now and into the future. An integral part of the SDGs is the implementation of state-of-the-art innovation, especially in the least developed areas. The discussed concept is fully consistent with the Sustainable Development Goals (SDGs) addressed by European policies, in particular Goal 9: Industry, Innovation and infrastructure because cooperation between society/farmers and stakeholders/clusters is key to the implementation of innovation in rural areas and the creation of infrastructure that will support regional economic development with active social participation.KeywordsSmall farmsFarmersSustainable agricultural policyAgro-clustersAgricultural policy

Biosensors are chemical sensors in which the recognition system utilizes a biochemical mechanism. The term biosensor has been variously used to a number of devices either used to monitor living system or incorporating biotic elements. The current consensus is that this term should be reserved for sensors incorporating a biological element such as an enzyme, antibody, nucleic acid, microorganism, or eukariotic cell where the biological element is in intimate contact with the transducer. The main purpose of the recognition system is to provide specificity to the biosensor, thus creating a device able to detect either a specific molecular target or a related family of compounds. The ability of biosensors to detect trace and low levels of biologically active substances is the main characteristic of these systems, and for this reason they have applications in the fields of medicine, biotechnology, food, and environmental science.

The enzyme-mimicking activity of iron oxide based nanostructures has provided a significant advantage in developing advanced molecular sensors for biomedical and environmental applications. Herein, we introduce the horseradish peroxidase (HRP)-like activity of gold-loaded nanoporous ferric oxide nanocubes (Au-NPFe2O3NC) for the development of a molecular sensor with enhanced electrocatalytic and colorimetric (naked eye) detection of autoantibodies. The results showed that Au-NPFe2O3NC exhibits enhanced peroxidase-like activity toward the catalytic oxidation of 3,3',5,5'-tertamethylbenzidine (TMB) in the presence of H2O2 at room temperature (25 °C) and follows the typical Michaelis-Menten kinetics. The autoantibody sensor based on this intrinsic property of Au-NPFe2O3NC resulted in excellent detection sensitivity [limit of detection (LOD) = 0.08 U/mL] and reproducibility [percent relative standard deviation (% RSD) = <5% for n = 3] for analyzing p53-specific autoantibodies using electrochemical and colorimetric (naked eye) readouts. The clinical applicability of the sensor has been tested in detecting p53-specific autoantibody in plasma obtained from patients with epithelial ovarian cancer high-grade serous subtype (EOCHGS, number of samples = 2) and controls (benign, number of samples = 2). As Au-NPFe2O3NC possess high peroxidase-like activity for the oxidation of TMB in the presence of H2O2 [TMB is a common chromogenic substrate for HRP in enzyme-linked immunosorbent assays (ELISAs)], we envisage that our assay could find a wide range of application in developing ELISA-based sensing approaches in the fields of medicine (i.e., detection of other biomarkers the same as p53 autoantibody), biotechnology, and environmental sciences.

This article highlights an emerging field known as synthetic biology that envisions integrating designed circuits into living organisms in order to instruct them to make logical decisions based on the prevailing intracellular and extracellular conditions and produce a reliable behavior. The attempt is to design cells capable of sensing a bioweapon or an environmental pollutant, activate its degradation pathway and perform bioremediation or carry out programmed cell death or synthesize complex biomaterials. Within the living cell, a complex interplay of networks formed by genes and proteins mediate all cellular processes. The networks in a system can be dissected into small regulatory gene circuit modules. Synthetic biology attempts to construct and assemble such modules step by step, plug the modules together and modify them, in order to generate a desired behavior. The review gives an insight into the creation of gene circuits and discusses the potential applications in the field of biotechnology, medicine and environmental sciences.

The association of natural polymers with silica is a fruitful strategy to design novel hybrid structures with potential applications in the fields of biotechnology, medicine, and environmental sciences. Here we illustrate the principles of formation, the structure, and the properties of such biohybrid systems by the specific example of silica–pectin porous materials. The influence of the silica source, i.e., aqueous silicates and tetraethoxysilane (TEOS), was more specifically addressed. The alkoxide precursor may be associated with the polysaccharide in a wide range of concentrations. In contrast, the high initial viscosity and fast condensation rate of silicates limits the range of accessible compositions. Owing to weak interactions between the mineral and organic components, silicification does not improve the thermal stability of the polymer but has a strong impact on the water stability of the materials, which depends on the silica source. It is shown that the stability of the silica–pectin hybrid materials during enzymatic degradation is optimum for low carbohydrate content and high silica content, independently of the inorganic precursor.

The innovative activity not only gives enterprises the opportunity to increase the amount of income from economic activity. In the long term, the introduction of innovative technologies into production is almost the only way for a business to continue its existence. And the most effective indicator of the emergence and development of innovative technologies is their high potential for commercialization. The article examines the difference between the concepts of “commercialization” and “transfer”, classifies the main problems of commercialization of innovative technologies in Ukraine, examines the experience of Poland in the operation of technological parks in the country and their influence on the level of commercialization of innovative technologies. The advantages and disadvantages of such an approach to increasing the level of commercialization of technologies and whether technological parks are able to solve the main problems of commercialization in Ukraine are emphasized.

Subject/topic. The article is devoted to the scientific problem of sustainable development of the region. Issues of sustainable development have become acutely discussed in the international community at all levels of government, in connection with environmental pollution, ecosystem depletion, and climate warming. The problems of reducing the quality of life and the economic inexpediency of regional investment projects are added to environmental problems. The subject of the study is a methodological approach to forecasting the sustainable development of the region. Goals/objectives. The purpose of the study is to develop an author's methodological approach to forecasting the sustainable development of the region, taking into account its specific features and taking into account the accumulated experience in this area. Methodology. The research methodology was a systematic approach, which used: a retrospective analysis of significant indicators of regional development, approximation, statistical methods of information processing, correlation and regression analysis. The empirical basis of the study was Rosstat data on the socio-economic development of the regions. Results. The author's methodological approach to forecasting the sustainable development of the region includes methods and techniques for building an economic model and assessing its quality. A universal algorithm for the formation of an economic model for forecasting the sustainable development of the region has been developed. The selection of independent and dependent variables - factors influencing the sustainable development of the region - has been carried out. The presented economic model of forecasting the sustainable development of the region, developed on the basis of correlation and regression analysis, reflects the peculiarities of the development of a particular subject of the Russian Federation. The model is quite reliable from the point of view of statistical estimates, which makes it possible to conclude that it describes the sustainable development of the region with high probability. Conclusions/significance. The novelty of the study lies in the development of the author's methodological approach, which includes an algorithm for the formation of such an economic model, which will identify social, environmental and economic factors affecting the sustainable development of the model region and assess the degree of their influence. As a result, it was possible to identify priority areas of activity of public authorities to achieve sustainable development of the Moscow region. Application. The proposed algorithm for forming an economic forecasting model is universal and can be applied to predict the sustainable development of other regions, taking into account the assessment of the quality of the economic model. The results obtained can be useful for substantiating management decisions of public authorities on the sustainable development of regional systems, forecasting the sustainable development of the region, taking into account its specific features affecting the development of the ecosystem.

Welcome to the MODEC2019 workshop. This is Amazon State University's (UEA) fourth workshop, devoted to the promotion and application of the Multidisciplinary Sciences to the development of natural products and agro-industrial processes in Ecuadorian Amazon regions. This includes the application of Information and Communications Technologies (ICTs) for data analysis and computational model including the fields of Agro-industrial Engineering, Chemistry, Chemical Engineering, Biotechnology, Veterinary Medicine, and/or Environmental Sciences, etc. We invite you to visit the official web of the workshop: https://sciforum.net/conference/mol2net-05/modec-04